Research projects in Internal Medicine focus on the development of new protocols and techniques for the diagnostic and prognostic evaluation of liver, gastrointestinal, pulmonary and cardiac diseases, with an emphasis on identifying biomarkers and potential therapeutic targets.
Diagnosis and prognosis of liver diseases
o Circulating MicroRNAs to the diagnostic and prognostic evaluation of non-alcoholic fatty liver disease
o Circulating MicroRNAs to the diagnostic and prognostic evaluation of hepatocellular carcinoma
Chronic inflammation and carcinogenesis
o Circulating MicroRNAs as new biomarkers for the diagnosis and monitoring of inflammatory bowel diseases and colorectal cancer
o The role of colored Doppler-assisted abdominal ultrasonography on monitoring of the inflammatory activity of Crohn’s disease’s enteritis
Hepatic diseases and its complications
o Role of urinary biomarkers on the diagnosis and prognosis of acute kidney injury in cirrhosis
o Functional magnetic resonance imaging techniques for the noninvasive assessment of non-alcoholic fatty liver disease (NAFLD)
o Applicability of a hepatobiliary contrast (Primovist®) in the evaluation of hepatic function
o Translational genomics of hepatocellular carcinoma
o Neuropsychological follow-up and evaluation with magnetic resonance spectroscopy of the skull of patients submitted to liver transplantation
New imaging techniques for the diagnosis of pulmonary diseases
o Pulmonary inflammatory events in tuberculosis: a translational study
o Functional and structural investigation of the pulmonary parenchyma through advanced magnetic resonance techniques
o Molecular imaging in acute lung injury: translational studies
Evaluation of interstitial myocardial fibrosis with T1 mapping magnetic resonance in cardiac diseases
o Detection of interstitial fibrosis by magnetic resonance with t1 mapping in chagas’ disease.
o Doxorubicin effects in cardiomyocytes derived from induced pluripotent stem cells obtained from patients sensitive and resistant to the anthracycline cardiotoxicity – approved by our ethics committee diseases. In collaboration with Antonio Carlos Campos de Carvalho - Professor at Instituto de Biofísica Carlos Chagas Filho, UFRJ.
o Detection of diffuse interstitial fibrosis by t1 mapping magnetic resonance in congenital heart disease patients
o Prospective registry of long-term clinical treatment of AF patients seen by the arrhythmia group of the Rede D’Or. Evaluation of quality of treatment from emergency department to clinical follow-up, including invasive procedures such as ablation or cardiac device implantation.
Genetics in cardiology
o Genetic evaluation of cardiac channelopathies patients and their family members to detect genetic alterations and identify new variants or mutations. These variants/mutations will be studied posteriorly using human iPS. In collaboration with Olga Ferreira de Souza, Arrhythmia and Electrophysiology Service, Labs D’Or.
Renata Perez, MD, PhD
Research Coordinator - Internal Medicine
Andréa Silvestre de Sousa, MD, PhD
CV Lattes | Publications
Celeste Elia, MD, PhD
Clerio Francisco de Azevedo Filho, MD, PhD
Daniella Parente, MD, PhD
Heitor Siffert de Souza, MD, PhD
Renata Moll, MD, PhD
CV Lattes | Publications
Rosana Rodrigues, MD, PhD